A single nucleotide polymorphism in the bovine kit oncogene (Hardy-Zuckerman 4 feline sarcoma viral (v-kit) oncogene homolog)

A single nucleotide polymorphism in the bovine kit oncogene (Hardy-Zuckerman 4 feline sarcoma viral (v-kit) oncogene homolog).

BRAF (v-raf murine sarcoma viral oncogene homolog B1)

Multiple oncogenic mutations related to targeted therapy in nasopharyngeal carcinoma.

INTRODUCTION An increasing number of targeted drugs have been tested for the treatment of nasopharyngeal carcinoma (NPC). However, targeted therapy-related oncogenic mutations have not been fully evaluated. This study aimed to detect targeted therapy-related oncogenic mutations in NPC and to determine which targeted therapy might be potentially effective in treating NPC. METHODS By using the ...

Molecular Alterations of KIT Oncogene in Gliomas

Gliomas are the most common and devastating primary brain tumours. Despite therapeutic advances, the majority of gliomas do not respond either to chemo or radiotherapy. KIT, a class III receptor tyrosine kinase (RTK), is frequently involved in tumourigenic processes. Currently, KIT constitutes an attractive therapeutic target. In the present study we assessed the frequency of KIT overexpression...

P-196: Association rs3819392 Single Nucleotide Polymorphism within The KIT Gene with Azoospermic Male Infertility

Background: Recent studies have shown that KIT is expressed in the cytoplasm of the spermatogonia, acrosomal granules and leydig cells. Reduction in KIT expression in oligozoospermia with an increase in the germ cell apoptosis process. Three single-nucleotide polymorphisms (SNPs) have been identified and these have been studied to discover KIT role in the male infertility. The aim of this study...